Whipple s disease: a fatal mimic

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Symptomatic cardiomyopathy as a presentation in Whipple ' s disease

First described in 1907,' valid cases of Whipple's disease reported in the world literature to date number around 800. As originally suspected by Whipple, the condition is now considered to be of infective aetiology,2 although the nature of the infecting organism remains undefined. This rare multisystem disorder has a number of characteristics (see box). Cardiac involvement is unusual. Although...

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Whipple disease associated with giardiasis.

We tested 53 fixed duodenal biopsy samples from 25 patients with Whipple disease for the presence Giardia and 6 fresh duodenal biopsy samples for Giardia duodenalis DNA by polymerase chain reaction (PCR). We also used histological examination and PCR assay to determine the prevalence of G. duodenalis in duodenal biopsy samples from 150 control patients without Whipple disease. Three of 25 patie...

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MR of cerebral Whipple disease.

A case of cerebral Whipple disease is reported. MR findings of the brain are discussed in relation to neuropathologic lesions reported previously. Repeated MR investigations may serve as a valuable tool to evaluate long-term efficacy of treatment in cerebral Whipple disease.

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Whipple Disease Research Accelerates Kenneth

The face of Whipple disease is changing rapidly. The disease was originally described in 1907 by the pathologist George Hoyt Whipple [1], but it was not until 1961 that electron microscopic studies showed it definitively to be caused by bacteria [2, 3]. The causative organism could not be cultivated, and the cell wall ultrastructure was considered ambiguous, so there was even uncertainty as to ...

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Pulmonary hypertension associated with Whipple disease.

References 1 Hegewald MJ, Crapo RO. Respiratory physiology in pregnancy. Clin Chest Med 2011; 32: 1–13. 2 Melot C, Naeije R. Pulmonary vascular diseases. Compr Physiol 2011; 1: 593–619. 3 Cutts BA, Dasgupta D, Hunt BJ. New directions in the diagnosis and treatment of pulmonary embolism in pregnancy. Am J Obstet Gynecol 2013; 208: 102–108. 4 Pernot J, Puzenat E, Magy-Bertrand N, et al. Detection...

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ژورنال

عنوان ژورنال: Autopsy Case Reports

سال: 2020

ISSN: 2236-1960

DOI: 10.4322/acr.2020.237